On the basis of animal experiments, some authors recommend a routine combination of
therapeutic plasma exchange in patients with immunologically mediated disorders, such as
autoimmune and immune complex diseases, with administration of cytotoxic drugs to
prevent overshoot in plasma levels of pathogenic components after plasma exchange. We
examined one healthy volunteer, seven patients with nonimmunologic diseases, and seven
patients with immunologically mediated disorders (six with non-organ specific and one with …