[HTML][HTML] Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of β1 integrin-mediated hematopoietic cell adhesion
A Arai, Y Nosaka, E Kanda, K Yamamoto… - Journal of Biological …, 2001 - ASBMB
The CrkL adaptor protein is involved in signaling from the receptor for erythropoietin (Epo)
as well as interleukin (IL)-3 and activates β 1 integrin-mediated hematopoietic cell adhesion
through its interaction with C3G, a guanine nucleotide exchange factor for Rap1. We
demonstrate here that Epo as well as IL-3 activates Rap1 in an IL-3-dependent
hematopoietic cell line, 32D, expressing the Epo receptor. The cytokine-induced activation
of Rap1 was augmented in cells that inducibly overexpress CrkL or C3G. The CrkL …
as well as interleukin (IL)-3 and activates β 1 integrin-mediated hematopoietic cell adhesion
through its interaction with C3G, a guanine nucleotide exchange factor for Rap1. We
demonstrate here that Epo as well as IL-3 activates Rap1 in an IL-3-dependent
hematopoietic cell line, 32D, expressing the Epo receptor. The cytokine-induced activation
of Rap1 was augmented in cells that inducibly overexpress CrkL or C3G. The CrkL …