[HTML][HTML] Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling …
K Pruitt, AS Ulku, K Frantz, RJ Rojas… - Journal of Biological …, 2005 - ASBMB
The apoptosis-promoting protein Par-4 has been shown to be down-regulated in Ras-
transformed NIH 3T3 fibroblasts through the Raf/MEK/ERK MAPK pathway. Because
mutations of the ras gene are most often found in tumors of epithelial origin, we explored the
signaling pathways utilized by oncogenic Ras to down-regulate Par-4 in RIE-1 and rat
ovarian surface epithelial (ROSE) cells. We determined that constitutive activation of the Raf,
phosphatidylinositol 3-kinase, or Ral guanine nucleotide exchange factor effector pathway …
transformed NIH 3T3 fibroblasts through the Raf/MEK/ERK MAPK pathway. Because
mutations of the ras gene are most often found in tumors of epithelial origin, we explored the
signaling pathways utilized by oncogenic Ras to down-regulate Par-4 in RIE-1 and rat
ovarian surface epithelial (ROSE) cells. We determined that constitutive activation of the Raf,
phosphatidylinositol 3-kinase, or Ral guanine nucleotide exchange factor effector pathway …