[HTML][HTML] Ô‖ Identification of GRY-RBP as an Apolipoprotein B RNA-binding Protein That Interacts with Both Apobec-1 and Apobec-1 Complementation Factor to …
C to U editing of apolipoprotein B (apoB) mRNA involves the interaction of a multicomponent
editing enzyme complex with a requisite RNA sequence embedded within an AU-rich
context. This enzyme complex includes apobec-1, an RNA-specific cytidine deaminase, and
apobec-1 complementation factor (ACF), a novel 65-kDa RNA-binding protein, that together
represent the minimal core of the editing enzyme complex. The precise composition of the
holo-enzyme, however, remains unknown. We have previously isolated an enriched fraction …
editing enzyme complex with a requisite RNA sequence embedded within an AU-rich
context. This enzyme complex includes apobec-1, an RNA-specific cytidine deaminase, and
apobec-1 complementation factor (ACF), a novel 65-kDa RNA-binding protein, that together
represent the minimal core of the editing enzyme complex. The precise composition of the
holo-enzyme, however, remains unknown. We have previously isolated an enriched fraction …