Eukaryotic cells have evolved strategies to respond to stress conditions. For example,
autophagy in yeast is primarily a response to the stress of nutrient limitation. Autophagy is a
catabolic process for the degradation and recycling of cytosolic, long lived, or aggregated
proteins and excess or defective organelles. In this study, we demonstrate a new pathway
for the induction of autophagy. In the endoplasmic reticulum (ER), accumulation of misfolded
proteins causes stress and activates the unfolded protein response to induce the expression …