[HTML][HTML] The B domain of coagulation factor VIII interacts with the asialoglycoprotein receptor
N Bovenschen, DC Rijken, LM Havekes… - Journal of Thrombosis …, 2005 - Elsevier
Summary Background: Coagulation factor VIII (FVIII) is a heavily glycosylated heterodimeric
plasma protein that consists of a heavy (domains A1‐A2‐B) and light chain (domains A3‐C1‐
C2). It has been well established that the clearance of FVIII from the circulation involves
mechanisms that are sensitive to the low‐density lipoprotein receptor (LDLR) family
antagonist receptor‐associated protein (RAP), including LDLR‐related protein. Because
FVIII clearance in the presence of a bolus injection of RAP still occurs fairly efficient, also …
plasma protein that consists of a heavy (domains A1‐A2‐B) and light chain (domains A3‐C1‐
C2). It has been well established that the clearance of FVIII from the circulation involves
mechanisms that are sensitive to the low‐density lipoprotein receptor (LDLR) family
antagonist receptor‐associated protein (RAP), including LDLR‐related protein. Because
FVIII clearance in the presence of a bolus injection of RAP still occurs fairly efficient, also …