Cutting edge: CD28 controls peripheral homeostasis of CD4+ CD25+ regulatory T cells
Q Tang, KJ Henriksen, EK Boden… - The Journal of …, 2003 - journals.aai.org
Q Tang, KJ Henriksen, EK Boden, AJ Tooley, J Ye, SK Subudhi, XX Zheng, TB Strom…
The Journal of Immunology, 2003•journals.aai.orgCD28/B7 blockade leads to exacerbated autoimmune disease in the nonobese diabetic
mouse strain as a result of a marked reduction in the number of CD4+ CD25+ regulatory T
cells (Tregs). Herein, we demonstrate that CD28 controls both thymic development and
peripheral homeostasis of Tregs. CD28 maintains a stable pool of peripheral Tregs by both
supporting their survival and promoting their self-renewal. CD28 engagement promotes
survival by regulating IL-2 production by conventional T cells and CD25 expression on …
mouse strain as a result of a marked reduction in the number of CD4+ CD25+ regulatory T
cells (Tregs). Herein, we demonstrate that CD28 controls both thymic development and
peripheral homeostasis of Tregs. CD28 maintains a stable pool of peripheral Tregs by both
supporting their survival and promoting their self-renewal. CD28 engagement promotes
survival by regulating IL-2 production by conventional T cells and CD25 expression on …
Abstract
CD28/B7 blockade leads to exacerbated autoimmune disease in the nonobese diabetic mouse strain as a result of a marked reduction in the number of CD4+ CD25+ regulatory T cells (Tregs). Herein, we demonstrate that CD28 controls both thymic development and peripheral homeostasis of Tregs. CD28 maintains a stable pool of peripheral Tregs by both supporting their survival and promoting their self-renewal. CD28 engagement promotes survival by regulating IL-2 production by conventional T cells and CD25 expression on Tregs.
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