The VEGF-C/VEGFR3 signaling pathway contributes to resolving chronic skin inflammation by activating lymphatic vessel function
A Hagura, J Asai, K Maruyama, H Takenaka… - Journal of …, 2014 - Elsevier
Background The functions of lymphatic vessels are to drain the protein-rich lymph from the
extracellular space, to maintain normal tissue pressure, and to mediate the immune
response, particularly in inflammatory conditions. Objective To evaluate the function of the
vascular endothelial growth factor (VEGF)-C/VEGF receptor (VEGFR)-3 signaling pathway in
chronic skin inflammation. Methods We used adenovirus-mediated VEGF-C or VEGFR3-
immunoglobulin (Ig) production and investigated the effects of VEGF-C/VEGFR3 signaling …
extracellular space, to maintain normal tissue pressure, and to mediate the immune
response, particularly in inflammatory conditions. Objective To evaluate the function of the
vascular endothelial growth factor (VEGF)-C/VEGF receptor (VEGFR)-3 signaling pathway in
chronic skin inflammation. Methods We used adenovirus-mediated VEGF-C or VEGFR3-
immunoglobulin (Ig) production and investigated the effects of VEGF-C/VEGFR3 signaling …