Heterodimeric receptors of the β1 and β3 integrin families mediate platelet adhesion and
aggregation in hemostasis and thrombosis. In resting platelets, integrins are expressed in a
low-affinity state but they shift to a high-affinity state and efficiently bind their ligands in
response to cellular activation. This review summarizes recent advances in understanding
the functional regulation and (patho-) physiological significance of individual platelet
integrins with a special focus on studies in genetically modified mice. It is now recognized …