[HTML][HTML] Characterization of Fas (Apo-1, CD95)-fas ligand interaction
P Schneider, JL Bodmer, N Holler, C Mattmann… - Journal of Biological …, 1997 - ASBMB
The death-inducing receptor Fas is activated when cross-linked by the type II membrane
protein Fas ligand (FasL). When human soluble FasL (sFasL, containing the extracellular
portion) was expressed in human embryo kidney 293 cells, the threeN-linked glycans of
each FasL monomer were found to be essential for efficient secretion. Based on the
structure of the closely related lymphotoxin α-tumor necrosis factor receptor I complex, a
molecular model of the FasL homotrimer bound to three Fas molecules was generated using …
protein Fas ligand (FasL). When human soluble FasL (sFasL, containing the extracellular
portion) was expressed in human embryo kidney 293 cells, the threeN-linked glycans of
each FasL monomer were found to be essential for efficient secretion. Based on the
structure of the closely related lymphotoxin α-tumor necrosis factor receptor I complex, a
molecular model of the FasL homotrimer bound to three Fas molecules was generated using …