[HTML][HTML] Fas-, caspase 8-, and caspase 3-dependent signaling regulates the activity of the aminophospholipid translocase and phosphatidylserine externalization in …
D Mandal, A Mazumder, P Das, M Kundu… - Journal of Biological …, 2005 - ASBMB
Apoptosis and erythrocyte senescence share the common feature of exposure of
phosphatidylserine (PS) in the outer leaflet of the cells. Western analysis showed that
mature red cells contain Fas, FasL, Fas-associated death domain (FADD), caspase 8, and
caspase 3. Circulating, aged cells showed colocalization of Fas with the raft marker proteins
Gα s and CD59; the existence of Fas-associated FasL, FADD and caspase 8; and caspase 8
and caspase 3 activity. Aged red cells had significantly lower aminophospholipid …
phosphatidylserine (PS) in the outer leaflet of the cells. Western analysis showed that
mature red cells contain Fas, FasL, Fas-associated death domain (FADD), caspase 8, and
caspase 3. Circulating, aged cells showed colocalization of Fas with the raft marker proteins
Gα s and CD59; the existence of Fas-associated FasL, FADD and caspase 8; and caspase 8
and caspase 3 activity. Aged red cells had significantly lower aminophospholipid …