p40phox: the last NADPH oxidase subunit

JD Matute, AA Arias, MC Dinauer, PJ Patiņo - Blood Cells, Molecules, and …, 2005 - Elsevier
The phagocytic NADPH-oxidase is a multiprotein system activated during the inflammatory
response to produce superoxide anion (O2−), which is the substrate for formation of
additional reactive oxygen species (ROS). The importance of this system for innate immunity
is established by chronic granulomatous disease (CGD), a primary immunodeficiency
caused by defects in the NADPH oxidase. In this review, we present and discuss recent
knowledge about p40phox, the last NADPH oxidase component to be identified …