The effects of recurrent hypoglycaemia and opioid antagonists on the adrenal catecholamine synthetic capacity in a rat model of HAAF
M Senthilkumaran, L Bobrovskaya - Autonomic Neuroscience, 2018 - Elsevier
In this study, we investigated the effects of recurrent hypoglycaemia on the adrenal
catecholamine synthetic enzymes in a rat model of hypoglycaemia-associated autonomic
failure (HAAF). We found that plasma adrenaline was significantly reduced by about 50% in
response to recurrent hypoglycaemia versus single hypoglycaemia. However, tyrosine
hydroxylase (TH) protein and phosphorylation at Ser31 and Ser40 were increased in HAAF;
similarly, aromatic aminoacid decarboxylase protein was also increased indicating a likely …
catecholamine synthetic enzymes in a rat model of hypoglycaemia-associated autonomic
failure (HAAF). We found that plasma adrenaline was significantly reduced by about 50% in
response to recurrent hypoglycaemia versus single hypoglycaemia. However, tyrosine
hydroxylase (TH) protein and phosphorylation at Ser31 and Ser40 were increased in HAAF;
similarly, aromatic aminoacid decarboxylase protein was also increased indicating a likely …