[HTML][HTML] TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination

J Zhang, MM Hu, YY Wang, HB Shu - Journal of Biological Chemistry, 2012 - ASBMB
Viral infection activates several transcription factors including NF-κB and IRF3, which
collaborate to induce type I interferons (IFNs) and innate antiviral response. MITA (also
called STING) is a critical adaptor protein that links virus-sensing receptors to IRF3 activation
upon infection by both RNA and DNA pathogens. Here we show that the E3 ubiquitin ligase
tripartite motif protein 32 (TRIM32) ubiquitinated MITA and dramatically enhanced MITA-
mediated induction of IFN-β. Overexpression of TRIM32 potentiated virus-triggered IFNB1 …