Circulating mitochondrial DNA at the crossroads of mitochondrial dysfunction and inflammation during aging and muscle wasting disorders

A Picca, AMS Lezza, C Leeuwenburgh… - Rejuvenation …, 2018 - liebertpub.com
A Picca, AMS Lezza, C Leeuwenburgh, V Pesce, R Calvani, M Bossola, E Manes-Gravina…
Rejuvenation research, 2018liebertpub.com
Mitochondrial structural and functional integrity is maintained through the coordination of
several processes (eg, biogenesis, dynamics, mitophagy), collectively referred to as
mitochondrial quality control (MQC). Dysfunctional MQC and inflammation are hallmarks of
aging and are involved in the pathogenesis of muscle wasting disorders, including
sarcopenia and cachexia. One of the consequences of failing MQC is the release of
mitochondria-derived damage-associated molecular patterns (DAMPs). By virtue of their …
Abstract
Mitochondrial structural and functional integrity is maintained through the coordination of several processes (e.g., biogenesis, dynamics, mitophagy), collectively referred to as mitochondrial quality control (MQC). Dysfunctional MQC and inflammation are hallmarks of aging and are involved in the pathogenesis of muscle wasting disorders, including sarcopenia and cachexia. One of the consequences of failing MQC is the release of mitochondria-derived damage-associated molecular patterns (DAMPs). By virtue of their bacterial ancestry, these molecules can trigger an inflammatory response by interacting with receptors similar to those involved in pathogen-associated responses. Mitochondria-derived DAMPs, especially cell-free mitochondrial DNA, have recently been associated with conditions characterized by chronic inflammation, such as aging and degenerative diseases. Yet, their actual implication in the aging process and muscle wasting disorders is at an early stage of investigation. Here, we review the contribution of mitochondria-derived DAMPs to age-related systemic inflammation. We also provide arguments in support of the exploitation of such signaling pathways for the management of muscle wasting conditions.
Mary Ann Liebert