[HTML][HTML] Structure and function of enzymes of the Leloir pathway for galactose metabolism
HM Holden, I Rayment, JB Thoden - Journal of Biological Chemistry, 2003 - ASBMB
In most organisms, the conversion of-D-galactose to the more metabolically useful glucose 1-
phosphate is accomplished by the action of four enzymes that constitute the Leloir pathway
(Scheme 1). In the first step of this pathway,-D-galactose is epimerized to-D-galactose by
galactose mutarotase. The next step involves the ATP-dependent phosphorylation of-D-
galactose by galactokinase to yield galactose 1-phosphate. As indicated in Scheme 1, the
third enzyme in the pathway, galactose-1-phosphate uridylyltransferase, catalyzes the …
phosphate is accomplished by the action of four enzymes that constitute the Leloir pathway
(Scheme 1). In the first step of this pathway,-D-galactose is epimerized to-D-galactose by
galactose mutarotase. The next step involves the ATP-dependent phosphorylation of-D-
galactose by galactokinase to yield galactose 1-phosphate. As indicated in Scheme 1, the
third enzyme in the pathway, galactose-1-phosphate uridylyltransferase, catalyzes the …