[HTML][HTML] CREB-binding protein/p300 co-activation of crystallin gene expression
Q Chen, DH Dowhan, D Liang, DD Moore… - Journal of Biological …, 2002 - ASBMB
Although some of the transcription factors that are required for expression of crystallins
during lens development have been identified, the molecular interactions that contribute to
enhanced crystallin expression are not yet well defined. In this study, we designed
experiments to test whether the co-activators CREB-binding protein (CBP) and/or p300
interact with c-Maf, Prox-1, or Sox-1 to enhance transcription of crystallin genes. Promoter
regions from the mouse αA-, βB2-, and γF-crystallin genes were linked to a luciferase …
during lens development have been identified, the molecular interactions that contribute to
enhanced crystallin expression are not yet well defined. In this study, we designed
experiments to test whether the co-activators CREB-binding protein (CBP) and/or p300
interact with c-Maf, Prox-1, or Sox-1 to enhance transcription of crystallin genes. Promoter
regions from the mouse αA-, βB2-, and γF-crystallin genes were linked to a luciferase …