Mitochondria in nonalcoholic fatty liver disease

SH Caldwell, CY Chang, RK Nakamoto… - Clinics in liver …, 2004 - liver.theclinics.com
Nonalcoholic fatty liver (NAFL) is associated with fundamental issues of fat metabolism and
insulin resistance. These abnormalities have been linked to impairment of ATP homeostasis,
and a growing body of literature has reported mitochondrial abnormalities in various forms of
hepatic steatosis. The changes are evident as structural abnormalities, including greatly
increased size and the development of crystalline inclusions, and are usually regarded as
pathologic, reflecting either a protective or degenerative response to injury. Although the …