Abstract The 5-Hydroxymethylcytosine (5-hmC) is an epigenetic modification whose role in
the pathogenesis of metabolic-related complex diseases remains unexplored; 5-hmC
appears to be prevalent in the mitochondrial genome. The Ten-Eleven-Translocation (TET)
family of proteins is responsible for catalyzing the conversion of 5-methylcytosine to 5-hmC.
We hypothesized that epigenetic editing by 5-hmC might be a novel mechanism through
which nonalcoholic fatty liver disease (NAFLD)-associated molecular traits could be …