Mitochondrial dysfunction and complications associated with diabetes
R Blake, IA Trounce - Biochimica et Biophysica Acta (BBA)-General …, 2014 - Elsevier
R Blake, IA Trounce
Biochimica et Biophysica Acta (BBA)-General Subjects, 2014•ElsevierBackground Diabetes is a metabolic syndrome that results in chronically increased blood
glucose (hyperglycaemia) due to defects either in insulin secretion consequent to the loss of
beta cells in the pancreas (type 1) or to loss of insulin sensitivity in target organs in the
presence of normal insulin secretion (type 2). Long term hyperglycaemia can lead to a
number of serious health-threatening pathologies, or complications, especially in the kidney,
heart, retina and peripheral nervous system. Scope of review Here we summarise the …
glucose (hyperglycaemia) due to defects either in insulin secretion consequent to the loss of
beta cells in the pancreas (type 1) or to loss of insulin sensitivity in target organs in the
presence of normal insulin secretion (type 2). Long term hyperglycaemia can lead to a
number of serious health-threatening pathologies, or complications, especially in the kidney,
heart, retina and peripheral nervous system. Scope of review Here we summarise the …
Background
Diabetes is a metabolic syndrome that results in chronically increased blood glucose (hyperglycaemia) due to defects either in insulin secretion consequent to the loss of beta cells in the pancreas (type 1) or to loss of insulin sensitivity in target organs in the presence of normal insulin secretion (type 2). Long term hyperglycaemia can lead to a number of serious health-threatening pathologies, or complications, especially in the kidney, heart, retina and peripheral nervous system.
Scope of review
Here we summarise the current literature on the role of the mitochondria in complications associated with diabetes, and the limitations and potential of rodent models to explore new modalities to limit complication severity.
Major conclusions
Prolonged hyperglycaemia results in perturbation of catabolic pathways and in an over-production of ROS by the mitochondria, which in turn may play a role in the development of diabetic complications. Furthermore, current models don't offer a comprehensive recapitulation of these complications.
General significance
The onset of complications associated with type 1 diabetes can be varied, even with tightly controlled blood glucose levels. The potential role of inherited, mild mitochondrial dysfunction in accelerating diabetic complications, both in type 1 and 2 diabetes, remains unexplored. This article is part of a Special Issue entitled Frontiers of Mitochondrial Research.
Elsevier