The folate cycle is a new metabolic weakness of cancer

D Lee, CCL Wong - Molecular & Cellular Oncology, 2017 - Taylor & Francis
D Lee, CCL Wong
Molecular & Cellular Oncology, 2017Taylor & Francis
Cancer cells harness nutrients to support its rapid proliferation through metabolic
reprogramming. Our report identified folate cycle as a metabolic target in hepatocellular
carcinoma. Folate cycle stagnation via inhibition of its mitochondrial folate enzyme
methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) greatly induced oxidative
stress improving HCC cells' response to sorafenib.
Abstract
Cancer cells harness nutrients to support its rapid proliferation through metabolic reprogramming. Our report identified folate cycle as a metabolic target in hepatocellular carcinoma. Folate cycle stagnation via inhibition of its mitochondrial folate enzyme methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) greatly induced oxidative stress improving HCC cells' response to sorafenib.
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