Effect of caloric restriction on age-associated cancers

R Weindruch - Experimental gerontology, 1992 - Elsevier
Caloric restriction (CR) without malnutrition in mice and rats reduces the incidence of
spontaneous tumors and delays their appearance while increasing maximum life span.
These results depend largely on CR per se, and not on low intakes of fat or other nutrients.
Although most studies have tested CR imposed early in life, CR started in midadulthood also
retards cancer and aging. The way (s) by which CR impedes cancers remain unclear, but
possibilities include less cellular oxidative damage, retarded immunologic aging, hormonal …