Enhanced response of human head and neck cancer xenograft tumors to cisplatin combined with 2-deoxy-D-glucose correlates with increased 18F-FDG uptake as …

AL Simons, MA Fath, DM Mattson, BJ Smith… - International Journal of …, 2007 - Elsevier
PURPOSE: To determine whether the response of human head and neck cancer xenografts
to cisplatin (CIS) could be enhanced with 2-deoxy-d-glucose (2DG); whether 2-[18F]-fluoro-2-
deoxy-d-glucose (FDG) uptake correlated with responses to this drug combination; and
whether 2DG would enhance CIS-induced radiosensitization. METHODS AND MATERIALS:
Clonogenic survival responses to CIS+ 2DG were determined in FaDu and Cal-27 cells and
reduced/oxidized glutathione levels were monitored as parameters indicative of oxidative …