[HTML][HTML] Mitochondrial O 2⋅¯ and H2O2 Mediate Glucose Deprivation-induced Stress in Human Cancer Cells
IM Ahmad, N Aykin-Burns, JE Sim, SA Walsh… - Journal of Biological …, 2005 - ASBMB
The hypothesis that glucose deprivation-induced cytotoxicity in transformed human cells is
mediated by mitochondrial O 2⋅\¯ and H 2 O 2 was first tested by exposing glucose-
deprived SV40-transformed human fibroblasts (GM00637G) to electron transport chain
blockers (ETCBs) known to increase mitochondrial O 2⋅\¯ and H 2 O 2 production
(antimycin A (AntA), myxothiazol (Myx), or rotenone (Rot)). Glucose deprivation (2–8 h) in
the presence of ETCBs enhanced parameters indicative of oxidative stress (ie GSSG and …
mediated by mitochondrial O 2⋅\¯ and H 2 O 2 was first tested by exposing glucose-
deprived SV40-transformed human fibroblasts (GM00637G) to electron transport chain
blockers (ETCBs) known to increase mitochondrial O 2⋅\¯ and H 2 O 2 production
(antimycin A (AntA), myxothiazol (Myx), or rotenone (Rot)). Glucose deprivation (2–8 h) in
the presence of ETCBs enhanced parameters indicative of oxidative stress (ie GSSG and …