Mitochondrial dysfunction is a common phenotype in aging and cancer

KK Singh - Annals of the New York Academy of Sciences, 2004 - Wiley Online Library
Annals of the New York Academy of Sciences, 2004Wiley Online Library
An interesting clue with regard to molecular mechanisms underlying age‐associated
cancers is the apparent defect in mitochondrial function. Recent studies demonstrate a
progressive decline in mitochondrial function during aging. Studies have established that
the decline in mitochondrial function is due to the accumulation of mutations in mitochondrial
DNA. These observations suggest that the mitochondrial dysfunction that accompanies
aging may exert a major influence on carcinogenesis.
Abstract: An interesting clue with regard to molecular mechanisms underlying age‐associated cancers is the apparent defect in mitochondrial function. Recent studies demonstrate a progressive decline in mitochondrial function during aging. Studies have established that the decline in mitochondrial function is due to the accumulation of mutations in mitochondrial DNA. These observations suggest that the mitochondrial dysfunction that accompanies aging may exert a major influence on carcinogenesis.
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