Increased volume density of peripheral mitochondria in skeletal muscle of children with exercise intolerance

GJ Van Ekeren, EAM Cornelissen… - European journal of …, 1991 - Springer
GJ Van Ekeren, EAM Cornelissen, AM Stadhouders, RCA Sengers
European journal of pediatrics, 1991Springer
Muscle biopsies from 17 children with exercise intolerance and other miscellaneous
symptoms and signs showed changes in mitochondrial content. The patients could not be
classified according to known criteria. The histopathological changes were quantified by
morphometric analysis and the clinical data were statistically analysed to detect
intercorrelations. After a mean follow up period of 6.8 years (range 0.5–13.6), patients were
re-examined and the course of the disease was determined. No clinical entity could be …
Abstract
Muscle biopsies from 17 children with exercise intolerance and other miscellaneous symptoms and signs showed changes in mitochondrial content. The patients could not be classified according to known criteria. The histopathological changes were quantified by morphometric analysis and the clinical data were statistically analysed to detect intercorrelations. After a mean follow up period of 6.8 years (range 0.5–13.6), patients were re-examined and the course of the disease was determined. No clinical entity could be established. None of the patients showed aggravation of the exercise intolerance, but 71% noted no improvement. An increased volume density of peripheral mitochondria was shown in 59%. Based on clinical history, histopathological changes and course we suggest that some of these patients suffer from a yet unknown disturbance in energy metabolism. Recognition of these patients is important for appropriate counselling.
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