Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP) 1A
K Lingappan, W Jiang, L Wang, XI Couroucli… - Toxicology, 2015 - Elsevier
Sex-specific differences in pulmonary morbidity in adults and preterm infants are well
documented. Hyperoxia contributes to lung injury in experimental animals and humans.
Cytochrome P450 (CYP) 1A enzymes have been shown to play a mechanistic role in
hyperoxic lung injury (HLI) in animal models. Whether CYP1A enzymes contribute to gender-
specific differences in relation to HLI is unknown. In this investigation, we tested the
hypothesis that mice will display gender-specific differences in HLI, and that this …
documented. Hyperoxia contributes to lung injury in experimental animals and humans.
Cytochrome P450 (CYP) 1A enzymes have been shown to play a mechanistic role in
hyperoxic lung injury (HLI) in animal models. Whether CYP1A enzymes contribute to gender-
specific differences in relation to HLI is unknown. In this investigation, we tested the
hypothesis that mice will display gender-specific differences in HLI, and that this …