[HTML][HTML] Insulin protects pancreatic acinar cells from palmitoleic acid-induced cellular injury
A Samad, A James, J Wong, P Mankad… - Journal of Biological …, 2014 - ASBMB
Acute pancreatitis is a serious and sometimes fatal inflammatory disease where the
pancreas digests itself. The non-oxidative ethanol metabolites palmitoleic acid (POA) and
POA-ethylester (POAEE) are reported to induce pancreatitis caused by impaired
mitochondrial metabolism, cytosolic Ca 2+([Ca 2+] i) overload and necrosis of pancreatic
acinar cells. Metabolism and [Ca 2+] i are linked critically by the ATP-driven plasma
membrane Ca 2+-ATPase (PMCA) important for maintaining low resting [Ca 2+] i. The aim of …
pancreas digests itself. The non-oxidative ethanol metabolites palmitoleic acid (POA) and
POA-ethylester (POAEE) are reported to induce pancreatitis caused by impaired
mitochondrial metabolism, cytosolic Ca 2+([Ca 2+] i) overload and necrosis of pancreatic
acinar cells. Metabolism and [Ca 2+] i are linked critically by the ATP-driven plasma
membrane Ca 2+-ATPase (PMCA) important for maintaining low resting [Ca 2+] i. The aim of …