[HTML][HTML] The role of the histone methyltransferase enhancer of zeste homolog 2 (EZH2) in the pathobiological mechanisms underlying inflammatory bowel disease …
OF Sarmento, PA Svingen, Y Xiong, Z Sun… - Journal of Biological …, 2017 - ASBMB
Regulatory T (Treg) cells expressing the transcription factor FOXP3 play a pivotal role in
maintaining immunologic self-tolerance. We and others have shown previously that EZH2 is
recruited to the FOXP3 promoter and its targets in Treg cells. To further address the role for
EZH2 in Treg cellular function, we have now generated mice that lack EZH2 specifically in
Treg cells (EZH2 Δ/Δ FOXP3+). We find that EZH2 deficiency in FOXP3+ T cells results in
lethal multiorgan autoimmunity. We further demonstrate that EZH2 Δ/Δ FOXP3+ T cells lack …
maintaining immunologic self-tolerance. We and others have shown previously that EZH2 is
recruited to the FOXP3 promoter and its targets in Treg cells. To further address the role for
EZH2 in Treg cellular function, we have now generated mice that lack EZH2 specifically in
Treg cells (EZH2 Δ/Δ FOXP3+). We find that EZH2 deficiency in FOXP3+ T cells results in
lethal multiorgan autoimmunity. We further demonstrate that EZH2 Δ/Δ FOXP3+ T cells lack …