MEL1S, not MEL1, is overexpressed in myelodysplastic syndromes patients with t (1; 3)(p36; q21)
Z Xiao, M Zhang, X Liu, Y Zhang, L Yang, Y Hao - Leukemia research, 2006 - Elsevier
Balanced chromosomal translocations rarely occur in myelodysplastic syndromes (MDS).
We describe here in three further Chinese patients with myelodysplastic syndromes (MDS)
whose cytogenetic analysis showed t (1; 3)(p36; q21). We detected the expression pattern of
MEL1 and MEL1s in BM of two healthy subjects and the three patients, and found that the
expression of MEL1s was overexpressed in MDS patients with t (1; 3)(p36; q21). Our
findings combined previous observations reported in literature support that MDS patients …
We describe here in three further Chinese patients with myelodysplastic syndromes (MDS)
whose cytogenetic analysis showed t (1; 3)(p36; q21). We detected the expression pattern of
MEL1 and MEL1s in BM of two healthy subjects and the three patients, and found that the
expression of MEL1s was overexpressed in MDS patients with t (1; 3)(p36; q21). Our
findings combined previous observations reported in literature support that MDS patients …