[HTML][HTML] The function of steroid hormone receptors is inhibited by the hsp90-specific compound geldanamycin
B Segnitz, U Gehring - Journal of Biological Chemistry, 1997 - ASBMB
The ansamycin antibiotic geldanamycin, which specifically interacts with the heat shock
protein hsp90, was used to study the function of hsp90 in steroid hormone receptors. We
observed inhibition of glucocorticoid-specific gene induction in several responsive cell
systems. Hormone binding abilities of receptors for glucocorticoid, progestin, androgen, and
estrogen were inhibited upon exposing intact cells to geldanamycin. Inhibition was only
seen when geldanamycin was applied to cell cultures under growth conditions or was …
protein hsp90, was used to study the function of hsp90 in steroid hormone receptors. We
observed inhibition of glucocorticoid-specific gene induction in several responsive cell
systems. Hormone binding abilities of receptors for glucocorticoid, progestin, androgen, and
estrogen were inhibited upon exposing intact cells to geldanamycin. Inhibition was only
seen when geldanamycin was applied to cell cultures under growth conditions or was …