Impaired function of regulatory T cells in patients with psoriasis is mediated by phosphorylation of STAT3
L Yang, B Li, E Dang, L Jin, X Fan, G Wang - Journal of dermatological …, 2016 - Elsevier
Background Psoriasis is a T cell-mediated chronic inflammatory skin disease. Regulatory T
cells (Tregs) are crucial in suppressing immune response to maintain the immune balance.
Wheras Tregs from psoriatic patients showed poorly activity in suppressing activation of
responder T cells (Tresp), the mechanisms involved in this process are still unknown.
Objectives In this study, we investigated the possible role of STAT3 pathway in the
pathogenesis of dysfunctional Tregs in psoriasis. Methods The suppressive function and the …
cells (Tregs) are crucial in suppressing immune response to maintain the immune balance.
Wheras Tregs from psoriatic patients showed poorly activity in suppressing activation of
responder T cells (Tresp), the mechanisms involved in this process are still unknown.
Objectives In this study, we investigated the possible role of STAT3 pathway in the
pathogenesis of dysfunctional Tregs in psoriasis. Methods The suppressive function and the …