Attenuation of obliterative bronchiolitis by a CXCR4 antagonist in the murine heterotopic tracheal transplant model
J Xu, E Torres, AL Mora, H Shim, A Ramirez… - The Journal of heart and …, 2008 - Elsevier
BACKGROUND: Long-term success in lung transplantation is limited by obliterative
bronchiolitis (OB), yet the mechanism for this disease is not well understood. Chemokine
SDF-1 and its receptor, CXCR4, have been reported to be involved in several fibrogenic
processes by recruiting inflammatory and fibroblast progenitor cells into injured tissues. We
hypothesized that the SDF-1/CXCR4 axis also plays a role in the pathogenesis of OB.
METHODS: Using the mouse heterotopic allogeneic airway transplant model, we …
bronchiolitis (OB), yet the mechanism for this disease is not well understood. Chemokine
SDF-1 and its receptor, CXCR4, have been reported to be involved in several fibrogenic
processes by recruiting inflammatory and fibroblast progenitor cells into injured tissues. We
hypothesized that the SDF-1/CXCR4 axis also plays a role in the pathogenesis of OB.
METHODS: Using the mouse heterotopic allogeneic airway transplant model, we …