Molecular cloning and characterization of two putative G protein-coupled receptors which are highly expressed in the central nervous system
N Leng, G Gu, RB Simerly, ER Spindel - Molecular brain research, 1999 - Elsevier
We have cloned from a rat hypothalamic cDNA library two closely related G protein-coupled
receptors (GPCRs) which we have designated GPCR/CNS1 and GPCR/CNS2. The peptide
sequences of these two G protein-coupled receptors shared 42% identity with each other
and were next most closely related to the endothelin receptors and the bombesin-like
peptide receptors (approximately 25% identity). Northern blot analysis showed that both
GPCR/CNS1 and GPCR/CNS2 were very highly expressed in rat brain. In situ hybridization …
receptors (GPCRs) which we have designated GPCR/CNS1 and GPCR/CNS2. The peptide
sequences of these two G protein-coupled receptors shared 42% identity with each other
and were next most closely related to the endothelin receptors and the bombesin-like
peptide receptors (approximately 25% identity). Northern blot analysis showed that both
GPCR/CNS1 and GPCR/CNS2 were very highly expressed in rat brain. In situ hybridization …