P2X7 purinergic receptors and extracellular ATP mediate apoptosis of human monocytes/macrophages infected with Mycobacterium tuberculosis reducing the …
R Placido, G Auricchio, S Falzoni, L Battistini… - Cellular …, 2006 - Elsevier
Mycobacterium tuberculosis (MTB) is a monocyte/macrophage (M/M) parasite, which has
developed several mechanisms to survive and multiply intracellularly. On the other hand,
infected cells are engaged in the effort to reduce mycobacterial viability. On this ground, we
report that MTB infection predisposes M/M to a pro-apoptotic ATP-based signalling, which is
aimed at decreasing MTB replication. In fact, we show that mycobacterial infection leads to
an increased expression of P2X7 purinergic receptors, which is paralleled by intracellular …
developed several mechanisms to survive and multiply intracellularly. On the other hand,
infected cells are engaged in the effort to reduce mycobacterial viability. On this ground, we
report that MTB infection predisposes M/M to a pro-apoptotic ATP-based signalling, which is
aimed at decreasing MTB replication. In fact, we show that mycobacterial infection leads to
an increased expression of P2X7 purinergic receptors, which is paralleled by intracellular …