The effect of pegylated recombinant human leptin (PEG-OB) on weight loss and inflammatory status in obese subjects
CJ Hukshorn, FMH Van Dielen, WA Buurman… - International journal of …, 2002 - nature.com
CJ Hukshorn, FMH Van Dielen, WA Buurman, MS Westerterp-Plantenga, LA Campfield…
International journal of obesity, 2002•nature.comOBJECTIVE: To investigate whether weekly subcutaneous administration of 60 mg of long-
acting pegylated human leptin (PEG-OB) for 8 weeks was able to influence weight loss,
metabolic profile and inflammatory status of obese subjects on a mildly hypoenergetic diet
(deficit: 3.2 MJ/day). DESIGN: A prospective, randomized, double-blind and placebo-
controlled single-center trial. SUBJECTS: Twenty-eight healthy, obese subjects (16 women,
12 men; age 22–65 y; body mass index 27.7–38.7 kg/m 2). MEASUREMENTS: Bodyweight …
acting pegylated human leptin (PEG-OB) for 8 weeks was able to influence weight loss,
metabolic profile and inflammatory status of obese subjects on a mildly hypoenergetic diet
(deficit: 3.2 MJ/day). DESIGN: A prospective, randomized, double-blind and placebo-
controlled single-center trial. SUBJECTS: Twenty-eight healthy, obese subjects (16 women,
12 men; age 22–65 y; body mass index 27.7–38.7 kg/m 2). MEASUREMENTS: Bodyweight …
Abstract
OBJECTIVE: To investigate whether weekly subcutaneous administration of 60 mg of long-acting pegylated human leptin (PEG-OB) for 8 weeks was able to influence weight loss, metabolic profile and inflammatory status of obese subjects on a mildly hypoenergetic diet (deficit: 3.2 MJ/day).
DESIGN: A prospective, randomized, double-blind and placebo-controlled single-center trial.
SUBJECTS: Twenty-eight healthy, obese subjects (16 women, 12 men; age 22–65 y; body mass index 27.7–38.7 kg/m 2).
MEASUREMENTS: Bodyweight, metabolic profile (including lipids), C-reactive protein (CRP) and soluble TNF α-receptor (sTNF-R) 55 and 75 levels.
RESULTS: At the end of the study no significant differences in the delta or percentage weight loss between the placebo (n= 14) and PEG-OB (n= 14) groups was observed. Also the changes in metabolic profile, CRP, sTNF-R55 and R75 concentrations between the two groups after 8 weeks of treatment did not differ.
CONCLUSION: Weekly injection of 60 mg PEG-OB did not lead to additional weight loss after 8 weeks of treatment. Furthermore, PEG-OB administration did not affect the changes in metabolic profile and the inflammatory status of obese subjects.
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