Therapeutic efficacy of prosaposin-derived peptide on different models of allodynia
CG Jolivalt, KM Ramos, K Herbetsson, FS Esch… - Pain, 2006 - Elsevier
We have previously demonstrated that the prosaposin-derived 14-mer peptide TX14 (A)
prevents structural and functional abnormalities associated with peripheral neuropathy in
diabetic rats. Unusually, this neuroprotective peptide also exhibited acute anti-hyperalgesic
properties in the same model, suggesting a dual action of TX14 (A) that could allow
therapeutic targeting of both degenerative neuropathy and neuropathic pain. In the present
study, we have extended investigation of the anti-allodynic properties of TX14 (A) to a range …
prevents structural and functional abnormalities associated with peripheral neuropathy in
diabetic rats. Unusually, this neuroprotective peptide also exhibited acute anti-hyperalgesic
properties in the same model, suggesting a dual action of TX14 (A) that could allow
therapeutic targeting of both degenerative neuropathy and neuropathic pain. In the present
study, we have extended investigation of the anti-allodynic properties of TX14 (A) to a range …