Pael‐R is accumulated in Lewy bodies of Parkinson's disease
Annals of Neurology: Official Journal of the American Neurological …, 2004•Wiley Online Library
We examined the distribution of Pael‐R, a newly identified substrate for Parkin, in
Parkinson's disease (PD) and multiple system atrophy (MSA). Pael‐R, Parkin, α‐synuclein,
and ubiquitin accumulated in Lewy bodies (LBs) and neurites. Pael‐R was localized in the
core of LBs. Parkin and α‐synuclein accumulated in the halo, neuronal cell bodies, and
processes. These findings potentially suggest the involvement of Pael‐R in LB formation,
and protection role of Parkin in Pael‐R‐mediated neurotoxicity in PD. The absence of Pael …
Parkinson's disease (PD) and multiple system atrophy (MSA). Pael‐R, Parkin, α‐synuclein,
and ubiquitin accumulated in Lewy bodies (LBs) and neurites. Pael‐R was localized in the
core of LBs. Parkin and α‐synuclein accumulated in the halo, neuronal cell bodies, and
processes. These findings potentially suggest the involvement of Pael‐R in LB formation,
and protection role of Parkin in Pael‐R‐mediated neurotoxicity in PD. The absence of Pael …
Abstract
We examined the distribution of Pael‐R, a newly identified substrate for Parkin, in Parkinson's disease (PD) and multiple system atrophy (MSA). Pael‐R, Parkin, α‐synuclein, and ubiquitin accumulated in Lewy bodies (LBs) and neurites. Pael‐R was localized in the core of LBs. Parkin and α‐synuclein accumulated in the halo, neuronal cell bodies, and processes. These findings potentially suggest the involvement of Pael‐R in LB formation, and protection role of Parkin in Pael‐R‐mediated neurotoxicity in PD. The absence of Pael‐R and Parkin in glial cytoplasmic inclusions (GCIs) in MSA implies a distinct pathway involved in the formation of LBs and GCIs. Ann Neurol 2004
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