[HTML][HTML] Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in …

A Dar, O Kollet, T Lapidot - Experimental hematology, 2006 - Elsevier
The chemokine SDF-1 (CXCL12) and its receptor CXCR4 are involved in regulation of
migration, survival, and development of multiple cell types, including human hematopoietic
CD34+/CD38−/low and stromal STRO-1+ stem cells. During steady-state homeostasis,
CXCR4 is expressed by hematopoietic cells and also by stromal cells, which are the main
source for SDF-1 in the bone marrow (BM). Stress-induced modulations in SDF-1 and
CXCR4 levels participate in recruitment of immature and maturing leukocytes from the BM …