[HTML][HTML] Concentrative export from the endoplasmic reticulum of the γ-aminobutyric acid transporter 1 requires binding to SEC24D

H Farhan, V Reiterer, VM Korkhov, JA Schmid… - Journal of biological …, 2007 - ASBMB
Re-uptake of γ-aminobutyric acid (GABA) into presynaptic specializations is mediated by the
GABA transporter 1 (GAT1), a member of the SLC6 gene family. Here, we show that a motif
in the COOH terminus of GAT1 (566 RL 567), which is conserved in SLC6 family members,
is a binding site for the COPII coat component Sec24D. We also identified residues in
Sec24D (733 DD 734) that are required to support the interaction with GAT1 and two
additional family members, ie the transporters for serotonin and dopamine. We used three …