Germline variant in HSD3B1 (1245 A> C) and response to abiraterone acetate plus prednisone in men with new-onset metastatic castration-resistant prostate cancer
AW Hahn, DM Gill, RH Nussenzveig, A Poole… - Clinical Genitourinary …, 2018 - Elsevier
Abstract Background The HSD3B1 gene encodes the enzyme 3β-hydroxysteroid
dehydrogenase-1 (3βHSD1), which catalyzes adrenal androgen precursors into
dihydrotestosterone, the most potent androgen. Recently, the HSD3B1 (1245C) variant was
shown to predict shorter duration of response to androgen deprivation therapy with medical
or surgical castration in the setting of castration-sensitive prostate cancer (CSPC). The
HSD3B1 (1245C) variant also predicts longer duration of response to ketoconazole in men …
dehydrogenase-1 (3βHSD1), which catalyzes adrenal androgen precursors into
dihydrotestosterone, the most potent androgen. Recently, the HSD3B1 (1245C) variant was
shown to predict shorter duration of response to androgen deprivation therapy with medical
or surgical castration in the setting of castration-sensitive prostate cancer (CSPC). The
HSD3B1 (1245C) variant also predicts longer duration of response to ketoconazole in men …
