The structure and function of the blood clot has been associated with altered risk of
thrombosis. Dense fibrin structures with small pores increase the risk of thrombosis, and
have major functional consequences by increasing the resistance to fibrinolysis and altering
the visco-elastic properties of the clot. However, while the structural changes to the overall
fibrin network have been extensively characterised, little is known regarding the intrafibrillar
structure of fibrin, the way protofibrils are arranged inside the fibrin fibers and the functional …