PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T-cell infiltration into pancreatic tumors
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis due to late detection and
resistance to conventional therapies. Published studies show that the PDA tumor
microenvironment is predominantly infiltrated with immune suppressive cells and signals
that if altered, would allow effective immunotherapy. However, single-agent checkpoint
inhibitors including agents that alter immune suppressive signals in other human cancers
such as cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed death 1 (PD-1), and its …
resistance to conventional therapies. Published studies show that the PDA tumor
microenvironment is predominantly infiltrated with immune suppressive cells and signals
that if altered, would allow effective immunotherapy. However, single-agent checkpoint
inhibitors including agents that alter immune suppressive signals in other human cancers
such as cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed death 1 (PD-1), and its …