Molecular mechanisms of antisense drugs: RNase H
ST CROOKE - Antisense and Nucleic Acid Drug Development, 1998 - liebertpub.com
Antisense and Nucleic Acid Drug Development, 1998•liebertpub.com
DISCUSSION RNase H is an important family of enzymes. Antisense drugs often work
through an RNase-dependent mechanism. Thus, insights into the characteristics of the
enzyme provide crucial direction for future work in medicinal chemistry and molecular
pharmacology. The cloning and expression of human RNase H enzymes should provide
additional support for improved anti-sense therapeutics.
through an RNase-dependent mechanism. Thus, insights into the characteristics of the
enzyme provide crucial direction for future work in medicinal chemistry and molecular
pharmacology. The cloning and expression of human RNase H enzymes should provide
additional support for improved anti-sense therapeutics.
DISCUSSION
RNase H is an important family of enzymes. Antisense drugs often work through an RNase-dependent mechanism. Thus, insights into the characteristics of the enzyme provide crucial direction for future work in medicinal chemistry and molecular pharmacology. The cloning and expression of human RNase H enzymes should provide additional support for improved anti-sense therapeutics.
Mary Ann Liebert