[HTML][HTML] TIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP …
CJ Morrison, CM Overall - Journal of biological chemistry, 2006 - ASBMB
The important and distinct contribution that membrane type 2 (MT2)-matrix
metalloproteinase (MMP) makes to physiological and pathological processes is now being
recognized. This contribution may be mediated in part through MMP-2 activation by MT2-
MMP. Using Timp2-/-cells, we previously demonstrated that MT2-MMP activates MMP-2 to
the fully active form in a pathway that is TIMP-2-independent but MMP-2 hemopexin
carboxyl (C) domain-dependent. In this study cells expressing MT2-MMP as well as chimera …
metalloproteinase (MMP) makes to physiological and pathological processes is now being
recognized. This contribution may be mediated in part through MMP-2 activation by MT2-
MMP. Using Timp2-/-cells, we previously demonstrated that MT2-MMP activates MMP-2 to
the fully active form in a pathway that is TIMP-2-independent but MMP-2 hemopexin
carboxyl (C) domain-dependent. In this study cells expressing MT2-MMP as well as chimera …