[HTML][HTML] Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase

N Birsa, R Norkett, T Wauer, TET Mevissen… - Journal of Biological …, 2014 - ASBMB
Mitochondrial transport plays an important role in matching mitochondrial distribution to
localized energy production and calcium buffering requirements. Here, we demonstrate that
Miro1, an outer mitochondrial membrane (OMM) protein crucial for the regulation of
mitochondrial trafficking and distribution, is a substrate of the PINK1/Parkin mitochondrial
quality control system in human dopaminergic neuroblastoma cells. Moreover, Miro1
turnover on damaged mitochondria is altered in Parkinson disease (PD) patient-derived …