[HTML][HTML] Critical Role for Lysines 21 and 22 in Signal-induced, Ubiquitin-mediated Proteolysis of IkB-α (∗)
L Baldi, K Brown, G Franzoso, U Siebenlist - Journal of Biological Chemistry, 1996 - ASBMB
The NF-κB transcription factor induces rapid transcription of many genes in response to a
variety of extracellular signals. NF-κB is readily activated from normally inhibited cytoplasmic
stores by induced proteolytic degradation of IκB-α, a principal inhibitor of this transcription
factor. Following the inhibitor's degradation, NF-κB is free to translocate to the nucleus and
induce gene transcription. The IκB-α inhibitor is targeted for degradation by signal-induced
phosphorylation of two closely spaced serines in its NH 2 terminus (Ser 32 and Ser 36) …
variety of extracellular signals. NF-κB is readily activated from normally inhibited cytoplasmic
stores by induced proteolytic degradation of IκB-α, a principal inhibitor of this transcription
factor. Following the inhibitor's degradation, NF-κB is free to translocate to the nucleus and
induce gene transcription. The IκB-α inhibitor is targeted for degradation by signal-induced
phosphorylation of two closely spaced serines in its NH 2 terminus (Ser 32 and Ser 36) …