On the mechanism of prostacyclin and thromboxane A2 biosynthesis
M Hecker, V Ullrich - Journal of Biological Chemistry, 1989 - ASBMB
The present research describes studies which address the mechanism of prostacyclin (PGI
2) and thromboxane A 2 (TXA 2) biosynthesis. In addition to prostaglandin H 1 (PGH 1),
PGG 2, PGH 2, and PGH 3, also 8-iso-PGH 2, 13 (S)-hydroxy-PGH 2, and 15-keto-PGH 2
were applied to determine the substrate specificities and kinetics of prostacyclin and
thromboxane synthase in more detail. Human platelet thromboxane synthase converted
PGH 1, 8-iso-PGH 2, 13 (S)-hydroxy-PGH 2 and 15-keto-PGH 2 into the corresponding …
2) and thromboxane A 2 (TXA 2) biosynthesis. In addition to prostaglandin H 1 (PGH 1),
PGG 2, PGH 2, and PGH 3, also 8-iso-PGH 2, 13 (S)-hydroxy-PGH 2, and 15-keto-PGH 2
were applied to determine the substrate specificities and kinetics of prostacyclin and
thromboxane synthase in more detail. Human platelet thromboxane synthase converted
PGH 1, 8-iso-PGH 2, 13 (S)-hydroxy-PGH 2 and 15-keto-PGH 2 into the corresponding …