[HTML][HTML] The catalytic architecture of leukotriene C4 synthase with two arginine residues
H Saino, Y Ukita, H Ago, D Irikura, A Nisawa… - Journal of Biological …, 2011 - ASBMB
Leukotriene (LT) C 4 and its metabolites, LTD 4 and LTE 4, are involved in the pathobiology
of bronchial asthma. LTC 4 synthase is the nuclear membrane-embedded enzyme
responsible for LTC 4 biosynthesis, catalyzing the conjugation of two substrates that have
considerably different water solubility; that amphipathic LTA 4 as a derivative of arachidonic
acid and a water-soluble glutathione (GSH). A previous crystal structure revealed important
details of GSH binding and implied a GSH activating function for Arg-104. In addition, Arg-31 …
of bronchial asthma. LTC 4 synthase is the nuclear membrane-embedded enzyme
responsible for LTC 4 biosynthesis, catalyzing the conjugation of two substrates that have
considerably different water solubility; that amphipathic LTA 4 as a derivative of arachidonic
acid and a water-soluble glutathione (GSH). A previous crystal structure revealed important
details of GSH binding and implied a GSH activating function for Arg-104. In addition, Arg-31 …