[HTML][HTML] Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory …
A Maekawa, KF Austen, Y Kanaoka - Journal of Biological Chemistry, 2002 - ASBMB
The cysteinyl leukotrienes (cysLTs), leukotriene (LT) C 4, LTD 4, and LTE 4, are
proinflammatory lipid mediators generated in the mouse by hematopoietic cells such as
macrophages and mast cells. There are two mouse receptors for the cysLTs, CysLT 1
receptor (CysLT 1 R) and CysLT 2 R, which are 38% homologous and are located on mouse
chromosomes X and 14, respectively. To clarify the different roles of the CysLT 1 R and
CysLT 2 R in inflammatory responses in vivo, we generated CysLT 1 R-deficient mice by …
proinflammatory lipid mediators generated in the mouse by hematopoietic cells such as
macrophages and mast cells. There are two mouse receptors for the cysLTs, CysLT 1
receptor (CysLT 1 R) and CysLT 2 R, which are 38% homologous and are located on mouse
chromosomes X and 14, respectively. To clarify the different roles of the CysLT 1 R and
CysLT 2 R in inflammatory responses in vivo, we generated CysLT 1 R-deficient mice by …